| 8,11 % | The Vanguard Group, Inc. | 6 023 620 | 1 109 671 | 2023. 12. 31. |
| 6,56 % | BlackRock Institutional Trust Company, N.A. | 4 873 312 | 866 858 | 2023. 12. 31. |
| 5,47 % | Deep Track Capital LP | 4 063 676 | 517 241 | 2023. 12. 31. |
| 4,61 % | Boxer Capital, L.L.C. | 3 421 541 | 0 | 2023. 12. 31. |
| 4,33 % | OrbiMed Advisors, LLC | 3 219 359 | -749 229 | 2023. 12. 31. |
| 4,07 % | Marshall Wace LLP | 3 024 859 | 1 736 606 | 2023. 12. 31. |
| 3,87 % | Maverick Capital, Ltd. | 2 873 216 | 2 235 456 | 2023. 12. 31. |
| 3,66 % | T. Rowe Price Associates, Inc. | 2 718 785 | 1 198 993 | 2023. 12. 31. |
| 3,53 % | State Street Global Advisors (US) | 2 619 650 | 48 454 | 2023. 12. 31. |
| 3,48 % | Deerfield Management Company, L.P. | 2 584 376 | 1 004 802 | 2023. 12. 31. |
| 2,91 % | Point72 Asset Management, L.P. | 2 162 176 | 1 635 722 | 2023. 12. 31. |
| 2,82 % | ArrowMark Colorado Holdings, LLC | 2 096 808 | -299 474 | 2023. 12. 31. |
| 2,64 % | Perceptive Advisors LLC | 1 957 246 | 436 830 | 2023. 12. 31. |
| 2,17 % | Invus Public Equities Advisors, LLC | 1 615 348 | -201 272 | 2023. 12. 31. |
| 2,10 % | Pictet Asset Management Ltd. | 1 558 487 | 504 630 | 2023. 12. 31. |
| 14,55 % | Fidelity Management & Research Company LLC | 10 809 235 | 1 423 764 | 2023. 12. 31. |
| 1,91 % | Geode Capital Management, L.L.C. | 1 419 088 | 236 978 | 2023. 12. 31. |
| 1,78 % | BNP Paribas Asset Management USA, Inc. | 1 318 638 | 6911 | 2024. 03. 31. |
| 1,43 % | Medical Strategy GmbH | 1 060 325 | 0 | 2023. 12. 31. |
| 1,30 % | Dimensional Fund Advisors, L.P. | 968 405 | -42 964 | 2023. 12. 31. |
| 1,21 % | Lord, Abbett & Co. LLC | 897 346 | 296 196 | 2024. 02. 29. |
| 1,20 % | Fiera Capital Corporation | 893 456 | 522 | 2023. 12. 31. |
| 1,08 % | Woodline Partners LP | 802 182 | 610 809 | 2023. 12. 31. |
| 1,07 % | Islam Saqib | 791 271 | -233 414 | 2024. 03. 25. |
| 0,84 % | RTW Investments L.P. | 625 000 | 625 000 | 2023. 12. 31. |
| 0,75 % | Finepoint Capital LP | 556 928 | 0 | 2023. 12. 31. |
| 0,73 % | Northern Trust Investments, Inc. | 544 685 | 84 296 | 2023. 12. 31. |
| 0,70 % | Columbia Threadneedle Investments (US) | 520 255 | 295 530 | 2023. 12. 31. |
| 0,69 % | JP Morgan Asset Management | 511 980 | -6977 | 2023. 12. 31. |
| 0,69 % | Morgan Stanley & Co. LLC | 511 494 | 57 141 | 2023. 12. 31. |
| 0,67 % | Charles Schwab Investment Management, Inc. | 501 067 | 77 303 | 2023. 12. 31. |
| 0,67 % | Voloridge Investment Management, LLC | 500 749 | 426 246 | 2023. 12. 31. |
| 0,63 % | MFS Investment Management | 468 078 | 60 652 | 2023. 12. 31. |
| 0,63 % | Schonfeld Strategic Advisors LLC | 466 457 | 466 457 | 2023. 12. 31. |
| 0,56 % | Citadel Advisors LLC | 417 814 | 396 508 | 2023. 12. 31. |
| 0,50 % | Laurion Capital Management LP | 372 074 | 479 | 2023. 12. 31. |
| 0,50 % | Victory Capital Management Inc. | 369 367 | 328 127 | 2023. 12. 31. |
| 0,48 % | Jefferies LLC | 356 078 | 356 078 | 2023. 12. 31. |
| 0,46 % | Checkpoint Capital L.P. | 340 000 | 340 000 | 2023. 12. 31. |
| 0,45 % | Norges Bank Investment Management (NBIM) | 337 833 | -19 861 | 2023. 12. 31. |
| 0,45 % | Goldman Sachs & Company, Inc. | 335 069 | -93 151 | 2023. 12. 31. |
| 0,41 % | Lynch (Daniel S) | 301 849 | 0 | 2024. 03. 25. |
| 0,37 % | Candriam Belgium S.A. | 275 628 | 125 002 | 2023. 12. 31. |
| 0,37 % | Candriam Luxembourg S.A. | 275 619 | 0 | 2024. 02. 29. |
| 0,34 % | New York State Common Retirement Fund | 253 741 | 3987 | 2023. 12. 31. |
| 0,32 % | Bessemer Trust Company, N.A. (US) | 241 337 | 0 | 2023. 12. 31. |
| 0,27 % | BlackRock Financial Management, Inc. | 203 420 | 52 916 | 2023. 12. 31. |
| 0,26 % | Edris (Badreddin) | 195 629 | -22 473 | 2024. 03. 25. |
| 0,26 % | Darwin Global Management Ltd | 192 734 | 192 734 | 2023. 12. 31. |
| 0,26 % | BofA Global Research (US) | 191 116 | -388 066 | 2023. 12. 31. |
| 0,25 % | Smith (Lesley Mary) | 183 752 | -12 070 | 2024. 03. 25. |
| 0,24 % | TD Asset Management Inc. | 181 432 | 42 600 | 2023. 12. 31. |
| 0,24 % | Nuveen LLC | 179 319 | 33 228 | 2023. 12. 31. |
| 0,24 % | BNY Mellon Asset Management | 177 282 | 22 405 | 2023. 12. 31. |
| 0,23 % | Sphera Funds Management Ltd. | 170 270 | -149 641 | 2023. 12. 31. |
| 0,23 % | BlackRock Investment Management, LLC | 170 060 | 30 542 | 2023. 12. 31. |
| 0,21 % | Oracle Investment Management, Inc. | 157 083 | 157 083 | 2023. 12. 31. |
| 0,21 % | Invesco Advisers, Inc. | 156 244 | 133 061 | 2023. 12. 31. |
| 0,21 % | Barclays Bank PLC | 154 273 | 56 545 | 2023. 12. 31. |
| 0,19 % | Rafferty Asset Management LLC | 144 347 | -35 237 | 2023. 12. 31. |
| 0,19 % | M28 Capital Management LP | 142 800 | -54 900 | 2023. 12. 31. |
| 0,19 % | UBS Financial Services, Inc. | 139 672 | 108 966 | 2023. 12. 31. |
| 0,18 % | Driehaus Capital Management, LLC | 136 624 | -397 721 | 2023. 12. 31. |
| 0,18 % | Peregrine Capital Management, LLC | 136 009 | -23 469 | 2023. 12. 31. |
| 0,18 % | Susquehanna International Group, LLP | 130 659 | 90 429 | 2023. 12. 31. |
| 0,18 % | D. E. Shaw & Co., L.P. | 130 312 | 24 576 | 2023. 12. 31. |
| 0,17 % | Goldman Sachs Asset Management, L.P. | 126 206 | -38 051 | 2023. 12. 31. |
| 0,16 % | Jane Street Capital, L.L.C. | 121 596 | 83 392 | 2023. 12. 31. |
| 0,16 % | HRT Financial LP | 116 606 | 116 606 | 2023. 12. 31. |
| 0,15 % | Russell Investments Trust Company | 114 154 | 4359 | 2023. 12. 31. |
| 0,15 % | Manulife Investment Management (North America) Limited | 109 384 | 23 942 | 2023. 12. 31. |
| 0,14 % | JPMorgan Private Bank (United States) | 103 242 | 55 373 | 2023. 12. 31. |
| 0,14 % | Managed Account Advisors LLC | 102 563 | -67 535 | 2023. 12. 31. |
| 0,14 % | Bridger Management, LLC | 101 126 | 101 126 | 2023. 12. 31. |
| 0,13 % | Affinity Asset Advisors LLC | 100 000 | 58 419 | 2023. 12. 31. |
| 0,13 % | Tang Capital Management, LLC | 100 000 | 100 000 | 2023. 12. 31. |
| 0,13 % | Rhumbline Advisers Ltd. Partnership | 95 064 | 8672 | 2023. 12. 31. |
| 0,12 % | Schweizerische Nationalbank | 92 400 | 16 800 | 2023. 12. 31. |
| 0,12 % | BlackRock Advisors (UK) Limited | 91 307 | 4338 | 2024. 03. 31. |
| 0,11 % | UBS Asset Management (Americas), Inc. | 84 018 | 4410 | 2023. 03. 31. |
| 0,11 % | Wells Fargo Advisors | 80 410 | -4314 | 2023. 12. 31. |
| 0,11 % | Citi Investment Research (US) | 79 776 | 314 | 2023. 12. 31. |
| 0,10 % | UBS O'Connor LLC | 75 250 | -17 986 | 2023. 12. 31. |
| 0,10 % | Blackstone Alternative Solutions L.L.C. | 75 000 | 75 000 | 2023. 12. 31. |
| 0,10 % | Monashee Investment Management, LLC | 73 949 | 73 949 | 2023. 12. 31. |
| 0,10 % | CastleArk Management, LLC | 73 050 | 73 050 | 2023. 12. 31. |
| 0,09 % | Cinctive Capital Management LP | 68 862 | 68 862 | 2023. 12. 31. |
| 0,09 % | BlackRock Asset Management Ireland Limited | 67 704 | 4070 | 2023. 12. 31. |
| 0,09 % | AllianceBernstein L.P. | 66 390 | 0 | 2023. 12. 31. |
| 0,09 % | Envestnet Asset Management, Inc. | 66 127 | 4780 | 2023. 12. 31. |
| 0,09 % | Nomura Asset Management Co., Ltd. | 64 500 | -39 799 | 2023. 11. 30. |
| 0,09 % | Mutual of America Capital Management LLC | 64 214 | 64 214 | 2023. 12. 31. |
| 0,09 % | Ostrum Asset Management | 63 800 | 63 800 | 2023. 12. 31. |
| 0,09 % | Mellon Investments Corporation | 63 241 | 979 | 2023. 12. 31. |
| 0,08 % | BNP Paribas Asset Management UK Limited | 62 506 | 44 831 | 2024. 03. 31. |
| 0,08 % | Two Sigma Investments, LP | 61 386 | -2814 | 2023. 12. 31. |
| 0,08 % | Resolute Capital Asset Partners LLC | 60 000 | 60 000 | 2023. 12. 31. |
| 0,08 % | T. Rowe Price International Ltd | 57 785 | 22 063 | 2023. 12. 31. |
| 0,07 % | HOOPP Investment Management | 55 000 | 55 000 | 2023. 12. 31. |
| 0,07 % | Parametric Portfolio Associates LLC | 54 056 | -16 060 | 2023. 12. 31. |
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